Article

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

2021-10-07

Abstract excerpt

<h4>Objective</h4> Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied but causal links remain enigmatic. <h4>Design</h4> Obese individuals with or without T2D were included from two independent Dutch cohorts. Human data was translated in vitro and in vivo by using pancreatic islets from C57BL6/J mice and by injecting fl...

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Literature Corpus work: 4fe66cc3-f246-5a21-93df-8ea68fe95611
DOI: 10.1101/2021.10.07.463317

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