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Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

19 Aug 2022

Abstract excerpt

Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied, but causal links remain enigmatic. Obese individuals with or without T2D were included from two independent Dutch cohorts. Human data were translated in vitro and in vivo by using pancreatic islets from C57BL6/J mice and by injecting flagellin into obese mice. Flagellin...

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PMID: 35984746
DOI: 10.1080/19490976.2022.2111951

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