Article

Exautomate: A user-friendly tool for region-based rare variant association analysis (RVAA)

2019-05-24

Abstract excerpt

Region-based rare variant association analysis (RVAA) is a popular method to study rare genetic variation in large datasets, especially in the context of complex traits and diseases. Although this method shows great promise in increasing our understanding of the genetic architecture of complex phenotypes, performing a region-based RVAA can be challenging. The sequence kernel association test (SKAT) can be used to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4fbcd8a3-d43c-5347-bb77-f945f870afa4
DOI: 10.1101/649368

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exautomate: A user-friendly tool for region-based rare variant association analysis (RVAA)DOI 10.1101/649368Read

Rare-variant association testing for sequencing data with the sequence kernel association test.Semantic proximity Read

FFBSKAT: fast family-based sequence kernel association test.Semantic proximity Read

Enhancing genotype-phenotype association with optimized machine learning and biological enrichment methodsSemantic proximity Read

A general framework for detecting disease associations with rare variants in sequencing studies.Semantic proximity Read

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studiesSemantic proximity Read

RAVAR: a curated repository for rare variant-trait associations.Semantic proximity Read

A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.Semantic proximity Read

Rare variant testing of imputed data: an analysis pipeline typified.Semantic proximity Read

UK-Biobank Whole Exome Sequence Binary Phenome Analysis with Robust Region-based Rare Variant TestSemantic proximity Read

A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions.Semantic proximity Read

UK Biobank Whole-Exome Sequence Binary Phenome Analysis with Robust Region-Based Rare-Variant Test.Semantic proximity Read

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillationSemantic proximity Read