Article

A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila

2023-06-02

Abstract excerpt

<title>Abstract</title> <p>Sleep loss typically imposes negative effects on animal health. However, humans with a rare genetic mutation in the <italic>dec2 </italic>gene (<italic>dec2</italic><sup><italic>P384R</italic></sup>) present an exception; these individuals sleep less without the usual effects associated with sleep deprivation. Thus, it has been suggested that the <italic>dec2</italic><sup><italic>P384R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4eefc61f-eeb1-5d20-9050-7a4bcd4ba99f
DOI: 10.21203/rs.3.rs-2882949/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A familial natural short sleep mutation promotes healthy aging and extends lifespan in DrosophilaDOI 10.21203/rs.3.rs-2882949/v1Read

A familial natural short sleep mutation promotes healthy aging and extends lifespan in <i>Drosophila</i>Semantic proximity Read

Aging and the clock: Perspective from flies to humansSemantic proximity Read

Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster.Semantic proximity Read

Identifying sleep regulatory genes using a Drosophila model of insomnia.Semantic proximity Read

A bidirectional relationship between sleep and oxidative stress in Drosophila.Semantic proximity Read

Familial natural short sleep mutations reduce Alzheimer pathology in miceSemantic proximity Read

Exploring the versatility of Drosophila melanogaster as a model organism in biomedical research: a comprehensive reviewSemantic proximity Read

The Smurf transition: new insights on ageing from end-of-life studies in animal modelsSemantic proximity Read

<i>Drosophila</i> Modeling of Insomnia-Associated Genes Reveals Diverse Underlying Sleep PhenotypesSemantic proximity Read

Proteostasis-associated aging: lessons from a Drosophila modelSemantic proximity Read

Experimental selection for Drosophila survival in extremely low O(2) environment.Semantic proximity Read

Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions.Semantic proximity Read