Article

The Flexible, Extended Alpha Helix Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity

2022-06-14

Abstract excerpt

The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and SARS-CoV-2 have caused severe outbreaks. The CoV envelope (E) protein, an important contributor to the pathogenesis of severe hCoVs infections, may provide insight into this disparate severity of the disease. We, therefore, generated f...

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Literature Corpus work: 4ec01098-2621-52f9-b93a-eb0caca94fed
DOI: 10.20944/preprints202206.0201.v1

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