Article
Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004
Supekar Vinit M, Bruckmann Chiara, Ingallinella Paolo, Bianchi Elisabetta, Pessi Antonello, Carfí Andrea
Abstract excerpt
A coronavirus (CoV) has recently been identified as the causative agent of the severe acute respiratory syndrome (SARS) in humans. CoVs enter target cells through fusion of viral and cellular membranes mediated by the viral envelope glycoprotein S. We have determined by x-ray crystallography the structure of a proteolytically stable core fragment from the heptad repeat (HR) regions HR1 and HR2 of the SARS-CoV S...
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