NF-κB-Driven HIV-1 Gene Expression in Human Cells Is Independent of Poly(ADP-ribose) polymerase-1 Function

Abstract excerpt

The cellular enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is required for NF-κB to activate inflammatory and immune response gene expression. NF-κB is also an important transcription factor in HIV-1 gene expression during active replication and latency reactivation. Therefore, enhancing NF-κB signaling is an alternative for HIV-1 latency reactivation, but significant systemic side effects related to the NF-κB ro...

Topics

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• CRISPR and Genetic Engineering
• Gene Expression Regulation, Viral
• Genes, Reporter
• HIV Long Terminal Repeat
• NF-kappa B
• PARP inhibition in cancer therapy
• Poly(ADP-ribose) Polymerase Inhibitors
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

4e6dc95c-065e-56ea-b5db-f4d7ca7b8db9

DOI

10.1101/2025.03.10.642491