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NF-κB-Driven HIV-1 Gene Expression in Human Cells Is Independent of Poly(ADP-Ribose) Polymerase-1 Function

2025-03-12

Abstract excerpt

The cellular enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is required for NF-κB to activate inflammatory and immune response gene expression. NF-κB is also an important transcription factor in HIV-1 gene expression during active replication and latency reactivation. Therefore, enhancing NF-κB signaling is an alternative for HIV-1 latency reactivation, but significant systemic side effects related to the NF-κB ro...

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Literature Corpus work
2efc7a89-cb09-57cf-840a-797b5555fb7f
DOI
10.20944/preprints202503.0813.v1
Open publication

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NF-κB-Driven HIV-1 Gene Expression in Human Cells Is Independent of Poly(ADP-Ribose) Polymerase-1 FunctionDOI 10.20944/preprints202503.0813.v1
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