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The acquisition of clinically relevant amoxicillin resistance in <i>Streptococcus pneumoniae</i> requires ordered horizontal gene transfer of four loci

2021-12-18

Abstract excerpt

Understanding how antimicrobial resistance spreads is critical for optimal application of new treatments. In the naturally competent human pathogen Streptococcus pneumoniae , resistance to β-lactam antibiotics is mediated by recombination events in genes encoding the target proteins, resulting in reduced drug binding affinity. However, for the front-line antibiotic amoxicillin, the exact mechanism of resistance s...

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Literature Corpus work
4df67dfd-494b-5a63-b264-2e406f11d994
DOI
10.1101/2021.12.17.473165
Open publication

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The acquisition of clinically relevant amoxicillin resistance in <i>Streptococcus pneumoniae</i> requires ordered horizontal gene transfer of four lociDOI 10.1101/2021.12.17.473165
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