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A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway

2024-09-21

Abstract excerpt

The full extent of immune system conservation between prokaryotes and eukaryotes is unknown. However, recent research supports that a subset of bacterial antiphage proteins is conserved in eukaryotes and likely gave rise to key actors of mammalian immunity. Here, we show that the SIR2 protein domain, present in bacterial antiphage systems, plays a role in eukaryotic innate immunity. Through phylogenetic analysis,...

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Literature Corpus work
4da63d8b-dd26-53fc-8ed8-f530a3345f2f
DOI
10.1101/2024.09.18.613514
Open publication

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A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathwayDOI 10.1101/2024.09.18.613514
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