Article

Nicotinylation is a histone mark generated from the nicotinic acid metabolite nicotinyl-CoA

2024-09-16

Abstract excerpt

<title>Abstract</title> <p>Protein post-translational modifications (PTMs) are crucial for cancer growth and metastasis. Vitamin B3, a key precursor of NAD + and NADP+, however its epigenetic functions in physiology and disease remain unclear. Herein we report a nicotinic acid (NA), a component of vitamin B3, induces a histone PTM, lysine nicotinylation (Knic), and demonstrate 17 Knic site across core histones in...

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Literature Corpus work: 4d8d81db-c116-5656-88b1-e81c2c04da25
DOI: 10.21203/rs.3.rs-4384441/v1

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