Is CD27 Ligand the Cause of the Increased Incidence of Epilepsy? A mendelian randomization study

Abstract excerpt

<title>Abstract</title> <p>Background Epilepsy, a persistent neurological disorder, involves complex pathogenic processes where immunological factors may contribute. The role of CD27 ligand in epilepsy remains unknown. This investigation assesses whether CD27 ligand causally influence generalized and focal epilepsy using Mendelian randomization (MR). Methods We utilized GWAS summary data for CD27 ligand and for...

Topics

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• Cytokines
• Epilepsies, Partial
• Epilepsy
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

4d8c6c5c-c89a-5691-b72b-dcff2e82a9c3

DOI

10.21203/rs.3.rs-4889861/v1