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Article

Causal association between serum 25-hydroxyvitamin D levels and epilepsy: A two-sample bidirectional mendelian randomization study.

Epilepsy & behavior : E&B - 1 Mar 2025

Wu Zhanshen, Zhao Yang, Zhang Bo, Li Yanyan

Abstract excerpt

OBJECTIVE: The study aimed to investigate the causal relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and epilepsy using Mendelian randomization (MR), thereby addressing confounding and reverse causality issues in observational studies. METHODS: We employed a two-sample bidirectional MR design utilizing summary-level data from the IEU OpenGWAS project. Serum 25(OH)D levels were analyzed using the...

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Topics

Humans
Epilepsy
Mendelian Randomization Analysis
Vitamin D
Polymorphism, Single Nucleotide
Female

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Identifiers

PMID: 39823739
DOI: 10.1016/j.yebeh.2024.110253

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