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Article

Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway.

PLoS genetics - 1 May 2015

Dialynas George, Shrestha Om K, Ponce Jessica M, Zwerger Monika, Thiemann Dylan A, Young Grant H, Moore Steven A, Yu Liping, Lammerding Jan, Wallrath Lori L

Abstract excerpt

Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate filaments that form a network underlying the inner nuclear membrane, providing structural support for the nucleus and organizing the genome. To better understand the pathogenesis caused by mutant lamins, we performed a structural and functional analysis on...

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Topics

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Share to Homeostasis
Share to Kelch-Like ECH-Associated Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lamin Type A

Share to Muscular Dystrophies

Share to NF-E2-Related Factor 2

Share to Nuclear Lamina

Share to Protein Folding

Share to Sequestosome-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 25996830
DOI: 10.1371/journal.pgen.1005231
PMCID: PMC4440730

Genes

LMNA
SQSTM1

Provenance

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Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway.PMID 25996830Read ↗

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