Article

Efficacy, Pharmacokinetic and Toxicity Profiles of a Broadly SARS-CoV2 Neutralizing Antibody

2023-08-01

Abstract excerpt

We recently reported the isolation and characterization of an anti-SARS-CoV-2 antibody, called IgG-A7, that protected transgenic mice expressing the human angiotensin-converting enzyme 2 (hACE-2) from the infection with SARS-CoV-2 Wuhan. We show here that IgG-A7 protected 100% of the transgenic mice infected with Delta (B.1.617.2) and Omicron (B.1.1.529) at doses of 0.5 and 5 mg/kg, respectively. In addition, we s...

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Literature Corpus work: 4cf8bbaa-aa9c-591a-9a14-c638d8a6668a
DOI: 10.20944/preprints202308.0052.v1

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