Article

Esophageal cancer derived exosomes imbalance circulating Tfh/Tfr via EXO-PDL1 to promote immunosuppression

2023-06-27

Abstract excerpt

<h4>Background: </h4> Esophageal cancer (EC) is a deadly malignancy. Exosomal programmed death ligand 1 (EXO-PDL1) induces immune escape to promote tumor progression. Furthermore, the imbalance between circulating follicular helper T cells (Tfh) and circulating follicular regulatory T cells (Tfr) is related to the progression of many malignant tumors. However, the role of the EC derived EXO-PDL1 in circulating Tfh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99220bb5-7d47-55b3-bba7-a491af562ee9
DOI: 10.21203/rs.3.rs-3089394/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Esophageal cancer derived exosomes imbalance circulating Tfh/Tfr via EXO-PDL1 to promote immunosuppressionDOI 10.21203/rs.3.rs-3089394/v1Read

Esophageal cancer-derived exosomes imbalance Tfh/Tfr cell ratio in the tumor immune microenvironment via EXO-PDL1 to promote immunosuppressionSemantic proximity Read

Immune characteristics and genetic markers of esophageal cancer by single-cell analysis: Implications for immunotherapySemantic proximity Read

Identification of secretory factors associated with suppressive tumor microenvironment in esophageal cancerSemantic proximity Read

Tumor immune microenvironment and immune checkpoint inhibitors in esophageal squamous cell carcinoma.Semantic proximity Read

Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal CancerSemantic proximity Read

Roles of Cancer Exosomes in Immunosuppression and Immune EvasionSemantic proximity Read

Single cell sequencing revealed the mechanism of PD-1 resistance affected by the expression profile of peripheral blood immune cells in ESCCSemantic proximity Read

Global research trends in the tumor immune microenvironment of esophageal cancer from immune infiltration to clinical translationSemantic proximity Read

High expression of ELAVL1 predicts poor prognosis of Esophageal CarcinomaSemantic proximity Read

Circulating Tfh-Related Immune Profiles and Clinical Associations of Plasma CXCL13 in Esophageal CancerSemantic proximity Read

A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progressionSemantic proximity Read

EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-βSemantic proximity Read