Article

TMP-M2Align: A Topology-Aware Multiobjective Approach to the Multiple Sequence Alignment of Transmembrane Proteins

2025-10-02

Abstract excerpt

Transmembrane proteins (TMPs) constitute approximately 30% of the mammalian proteome and are critical targets in biomedical research due to their involvement in signaling, transport, and drug interactions. However, their unique structural characteristics pose significant challenges for conventional multiple sequence alignment (MSA) methods, which are typically optimized for soluble proteins. In this paper, we prop...

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Literature Corpus work: 4c3a39cf-b7db-5f49-8acb-ffd62d0688eb
DOI: 10.20944/preprints202510.0109.v1

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