Article

Oligogenic combinations of rare variants influence specific phenotypes in complex disorders

2021-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Genetic studies of complex disorders such as autism and intellectual disability (ID) are often based on enrichment of individual rare variants or their aggregate burden in affected individuals compared to controls. However, these studies overlook the influence of combinations of rare variants that may not be deleterious on their own due to statistical challenges resulting from rarity and combina...

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Literature Corpus work: 16f1c5fd-c419-578c-9609-e9b87899f884
DOI: 10.1101/2021.10.01.462832

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