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Article

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.

Journal of clinical and experimental hematopathology : JCEH - 1 Jan 2017

Tsuyama Naoko, Sakamoto Kana, Sakata Seiji, Dobashi Akito, Takeuchi Kengo

Abstract excerpt

Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30. In 1994, the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion receptor tyrosine kinase was identified in a subset of patients, leading to subdivision of this disease into ALK-positive and -negative ALCL in the present World...

Topics

Anaplastic Lymphoma Kinase
Animals
Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Doxorubicin
Humans
Ki-1 Antigen
Lymphoma, Large-Cell, Anaplastic
Mutation
Prednisolone
Protein Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor Protein-Tyrosine Kinases

Vincristine

Source

Open in PubMed Open full text

Identifiers

PMID: 29279550
DOI: 10.3960/jslrt.17023
PMCID: PMC6144189

Genes

ALK
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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