Article

Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markers

2021-02-10

Abstract excerpt

Patient derived models (PDMs) are a powerful tool to study preclinical responses. However, the benefits of each model have not been compared head-to-head when models are derived from the same surgical specimen. PDMs derived from surgical specimens were established as xenografts (PDX), organoids (PDO), and spheroids (PDS). PDMs were molecularly characterized by RNA sequencing. Differential gene expression was deter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b7caed7-dbb5-540c-bf00-13ef684955a2
DOI: 10.1101/2021.02.10.430614

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markersDOI 10.1101/2021.02.10.430614Read

Bridging phenotype and function in bladder cancer using immuno-competent organoids and ex vivo drug screening.Semantic proximity Read

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.Semantic proximity Read

Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastasesSemantic proximity Read

Bladder cancer organoids as a functional system to model different disease stages and therapy responseSemantic proximity Read

A bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid cultureSemantic proximity Read

Molecular subtypes of bladder cancer do not display microenvironment- or metastasis-induced plasticitySemantic proximity Read

Convergent biology, divergent drivers: a cross-species comparison of human and canine invasive urothelial carcinomaSemantic proximity Read

Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapiesSemantic proximity Read

Verification of molecular subtyping of bladder cancer in the GUSTO clinical trialSemantic proximity Read

Establishing a Canine Urothelial Organoid Repository: A Platform for Comparative and Translational Carcinoma StudiesSemantic proximity Read