Article

Intratracheal instillation of respiratory syncytial virus is superior to intranasal inoculation as a model method in mice and can induce infiltration of important immune cells

2024-11-20

Abstract excerpt

<title>Abstract</title> <p>Respiratory syncytial virus (RSV) causes a substantial global disease burden, particularly in children and older adults. Despite the availability of three vaccines and two prophylactic monoclonal antibodies, there remains an urgent unmet need for effective RSV treatments. Appropriate experimental animal models and modeling methods are essential to study the pathogenesis of RSV and devel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b59cef9-0ceb-535e-ab3f-c51ee486be9c
DOI: 10.21203/rs.3.rs-5175865/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intratracheal instillation of respiratory syncytial virus is superior to intranasal inoculation as a model method in mice and can induce infiltration of important immune cellsDOI 10.21203/rs.3.rs-5175865/v1Read

Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics.Semantic proximity Read

Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine DevelopmentSemantic proximity Read

Dynamics of interactions between three major respiratory pathogens in reconstituted human epitheliumSemantic proximity Read

Prediction of zoonotic virus-host transmissibility using comparative airway organoidsSemantic proximity Read

A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune ProtectionSemantic proximity Read

Immunomodulation in Respiratory Syncytial Virus Infection: Mechanisms, Therapeutic Targets, and Clinical ImplicationsSemantic proximity Read

A precision-cut lung slice platform for evaluating respiratory virus replication dynamicsSemantic proximity Read

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin VariantSemantic proximity Read

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized miceSemantic proximity Read

Animal Pneumoviruses: Molecular Genetics and PathogenesisSemantic proximity Read

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these yearsSemantic proximity Read

RSV--a substantial slice of the airway disease burden and the way to a vaccine.Semantic proximity Read