Article

LM-PROTAC: a language model-driven PROTAC generation pipeline with dual constraints of structure and property

2025-04-07

Abstract excerpt

<title>Abstract</title> <p>The imperfect modeling of ternary complexes has limited the application of computer-aided drug discovery tools in PROTAC research and development. In this study, a language model for PROTAC molecule design pipeline named LM-PROTAC was developed, which stands for language model-driven Proteolysis Targeting Chimera, by embedding a transformer-based generative model with dual constraints o...

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Literature Corpus work: 4b11e1e4-1bef-576f-aa00-428b284d769f
DOI: 10.21203/rs.3.rs-6356959/v1

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