Article

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

2018-09-07

Abstract excerpt

Our results highlight for the first time that a significant proportion of cell doublets in flow cytometry, previously believed to be the result of technical artefacts and thus ignored in data acquisition and analysis, are the result of true biological interaction between immune cells. In particular, we show that cell:cell doublets pairing a T cell and a monocyte can be directly isolated from human blood, and high...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b0d898f-b25d-5e84-80af-aa30e3b50b17
DOI: 10.1101/411553

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbationsDOI 10.1101/411553Read

The challenge of distinguishing cell-cell complexes from singlet cells in non-imaging flow cytometry and single-cell sortingSemantic proximity Read

The continuum of monocyte phenotypes: Experimental evidence and prognostic utility in assessing cardiovascular riskSemantic proximity Read

Identification of Novel Human Monocyte Subsets and Evidence for Phenotypic Groups Defined by Interindividual Variations of Expression of Adhesion Molecules.Semantic proximity Read

The Endless Saga of Monocyte DiversitySemantic proximity Read

A Two-Stage Flow Cytometry Strategy to Distinguish Single Cells from Doublets in Heterogeneous Cell Mixtures and Improve Cell Cluster Identification: Application to Human Monocyte Subpopulations.Semantic proximity Read

Monocyte Differentiation and Heterogeneity: Inter-Subset and Interindividual Differences.Semantic proximity Read

Comprehensive Phenotyping of Human Dendritic Cells and Monocytes.Semantic proximity Read

Functional crosstalk between T cells and monocytes in cancer and atherosclerosisSemantic proximity Read

Phenotypic and functional changes in peripheral blood monocytes during progression of human immunodeficiency virus infection. Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1-encoded proteins on monocytes phagocytic function, oxidative burst, transendothelial migration, and cell surface phenotype.Semantic proximity Read

Plasma membrane order maps functional diversity in immune cellsSemantic proximity Read

High-Content Immunophenotyping and Hierarchical Clustering Reveal Sources of Heterogeneity and New Surface Markers of Human Blood Monocyte Subsets.Semantic proximity Read

Circulating CD33+ large mononuclear cells contain three distinct populations with phenotype of putative antigen-presenting cells including myeloid dendritic cells and CD14+ monocytes with their CD16+ subset.Semantic proximity Read