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Single-Cell and Spatial Multi-Omics Unravel Estrogen-Driven Remodeling of the Prolapsed Uuterine Microenvironment via Fibroblast Reprogramming and Intercellular Communication

2025-10-31

Abstract excerpt

<title>Abstract</title> <p>The clinical paradox of local estrogen therapy in pelvic organ prolapse—its widespread application juxtaposed with inconsistent therapeutic outcomes—highlights a critical gap in our understanding of its actions within the native tissue architecture. To resolve this, we employed high-definition spatial transcriptomics, achieving a near-cellular resolution map of the postmenopausal vagina...

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Literature Corpus work: 03f6661a-f290-5413-b19c-e893b54b96c2
DOI: 10.21203/rs.3.rs-7983273/v1

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Single-Cell and Spatial Multi-Omics Unravel Estrogen-Driven Remodeling of the Prolapsed Uuterine Microenvironment via Fibroblast Reprogramming and Intercellular CommunicationDOI 10.21203/rs.3.rs-7983273/v1Read

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