Article

Haruka Resolves Perturbation Response Heterogeneity in Spatial Cell Niches

2025-12-11

Abstract excerpt

Understanding how tissues remodel in response to perturbations requires computational tools that can untangle condition-specific changes from the conserved tissue architecture. We present Haruka, a spatially aware contrastive learning framework that identifies salient (condition-specific) and background (shared) spatial domains across tissue slices and experimental conditions. Haruka integrates contrastive variati...

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Literature Corpus work: af4c8c0f-38c5-5c92-8d3b-fff44e63deec
DOI: 10.64898/2025.12.08.693051

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