Article

Progression of low-grade neuroendocrine tumors (NET) to high-grade neuroendocrine neoplasms harboring the prototypical neuroendocrine carcinoma (NEC) co-alteration of RB1 and TP53.

2024-10-17

Abstract excerpt

<title>Abstract</title> <p>High-grade or grade 3 epithelial neuroendocrine neoplasms (G3 NEN) are now divided into grade 3 well-differentiated neuroendocrine tumor (G3 NET) and neuroendocrine carcinoma (NEC), both defined by Ki-67 >20% and/or >20 mitoses per 2mm<sup>2</sup>. NET and NEC are thought to be distinct tumors with different genetic profiles: NEC classically harbor co-alteration of <italic>TP53</italic>...

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Literature Corpus work: 4abfb170-32b2-5a48-a345-c98baf5eec0e
DOI: 10.21203/rs.3.rs-4980226/v1

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