Article

Bridging the gap in embryogenesis research: North Bornean orangutan-derived blastoids as models for human development

2025-12-08

Abstract excerpt

<title>Abstract</title> <p> Understanding early primate embryogenesis remains limited by ethical and technical constraints. To address this, we established a stem cell-based embryo model from the North Bornean orangutan ( <italic>Pongo pygmaeus pygmaeus</italic> ). Using integration-free induced pluripotent stem cells (iPSCs), we generated blastoids that self-organized into structures resembling human blastocy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4ab8d7e3-1666-5470-9fcc-c0d1d0cc7901
DOI: 10.21203/rs.3.rs-8154543/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bridging the gap in embryogenesis research: North Bornean orangutan-derived blastoids as models for human developmentDOI 10.21203/rs.3.rs-8154543/v1Read

Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediatesSemantic proximity Read

Systematic evaluation of blastoid models of early human developmentSemantic proximity Read

Generation of human blastocyst-like structures from pluripotent stem cellsSemantic proximity Read

Human blastoid as an in vitro model of human blastocystsSemantic proximity Read

Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesisSemantic proximity Read

A protocol for the generation of blastocyst-like structures from human pluripotent stem cellsSemantic proximity Read

The mammalian blastocystSemantic proximity Read

The selection arena in early human blastocysts resolves the pluripotent inner cell massSemantic proximity Read

Human blastoids model blastocyst development and implantationSemantic proximity Read

Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming InnovationsSemantic proximity Read

Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naïve PSCsSemantic proximity Read

Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocystsSemantic proximity Read