Article
Molecular and functional characterization of human pendrin and its allelic variants.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2011
Dossena Silvia, Nofziger Charity, Tamma Grazia, Bernardinelli Emanuele, Vanoni Simone, Nowak Christoph, Grabmayer Elisabeth, Kössler Sonja, Stephan Susanne, Patsch Wolfgang, Paulmichl Markus
Abstract excerpt
Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I(-), Cl(-), HCO(3)(-), OH(-), SCN(-) and formate. In the thyroid, pendrin is expressed at the apical membrane of the follicular epithelium and may be involved in mediating apical iodide efflux into the follicle; in the inner ear, it plays a crucial role in the conditioning of the pH and ion composition of the endolymph; in the kidney, it...
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