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Repurposing Diphenhydramine in Non-Small Cell Lung Cancer: A Mitochondrial Redox Mechanism and a Derived Prognostic Gene Signature

2026-03-11

Abstract excerpt

<title>Abstract</title> <p>Diphenhydramine (DIPH) is a widely used first-generation H1 antihistamine. While multiple antihistamines have recently shown noteworthy anticancer potential, the therapeutic efficacy of DIPH in non-small cell lung cancer (NSCLC) and its underlying mechanisms of action remain unreported. Here, we demonstrate that DIPH potently suppresses the viability, clonogenicity, migration, and invas...

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Literature Corpus work
4a5030ce-9cb5-57d7-bef5-b61054ccaefe
DOI
10.21203/rs.3.rs-8900171/v1
Open publication

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Repurposing Diphenhydramine in Non-Small Cell Lung Cancer: A Mitochondrial Redox Mechanism and a Derived Prognostic Gene SignatureDOI 10.21203/rs.3.rs-8900171/v1
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