Article

Limitations of Gliadel Wafer and Strategies for Next-Generation Local Delivery Systems for Glioblastoma

2026-02-05

Abstract excerpt

<h4>Background: </h4> Local delivery after glioblastoma (GBM) resection aims to raise intratumoral drug exposure while limiting systemic toxicity. The only FDA-approved implantable therapy for GBM is the carmustine (BCNU)–impregnated polyanhydride wafer (Gliadel wafer). More than two decades of clinical use and randomized data show that intracavitary chemotherapy is feasible and confers a modest survival benefit i...

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Literature Corpus work: 4a31ff50-7734-528e-ba25-a9581d57b962
DOI: 10.20944/preprints202602.0366.v1

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