IsomiR Utility in Amyotrophic Lateral Sclerosis Prognostication

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss. IsomiRs are microRNA (miRNA) isoforms that arise from alternative processing or editing events during miRNA biogenesis. While isomiRs may carry distinct biological and clinical relevance, their potential as cell-free biomarkers in neurodegeneration remains...

Topics

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• Alzheimer's disease research and treatments
• Amyotrophic Lateral Sclerosis Research
• biodegradable polymer synthesis and properties
• Histone Deacetylase Inhibitors Research
• Neurogenetic and Muscular Disorders Research
• Prion Diseases and Protein Misfolding
• RNA Research and Splicing

Identifiers and source

Literature Corpus work

4a16fda5-1183-509f-8059-0048cbde6ec6

DOI

10.1101/2025.05.12.25325848