Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-based vaccines and innate immune activation: Not too hot and not too cold

12 Mar 2021

Abstract excerpt

RNA-based vaccine technology received a significant boost this past year with the approval of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines developed by Biotech/Pfizer and Moderna. In addition to such mRNA-based vaccines, self-amplifying RNA (sa-RNA) can also be used for vaccination.1 In addition to the transgene product, the sa-mRNA encodes an RNA-dependent RNA polymerase, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33705707
DOI: 10.1016/j.ymthe.2021.03.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-based vaccines and innate immune activation: Not too hot and not too coldPMID 33705707Read ↗

sa-mRNA influenza vaccine raises a higher and more durable immune response than mRNA vaccine in preclinical modelsSemantic proximity Read ↗

Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine DevelopmentSemantic proximity Read ↗

Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19Semantic proximity Read ↗

The Importance of RNA-Based Vaccines in the Fight against COVID-19: An OverviewSemantic proximity Read ↗

Vaccines’ New Era-RNA VaccineSemantic proximity Read ↗

The advent of clinical self-amplifying RNA vaccinesSemantic proximity Read ↗

In Gratitude for mRNA VaccinesSemantic proximity Read ↗

Advances in the design and delivery of RNA vaccines for infectious diseasesSemantic proximity Read ↗

RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?Semantic proximity Read ↗

Messenger Ribonucleic Acid (mRNA)-Based Universal Vaccines: Engineering Broad-Spectrum Immunity Against Future PandemicsSemantic proximity Read ↗

Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and HumansSemantic proximity Read ↗

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.