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Somatic CAG expansion in Huntington’s disease is dependent on the MLH3 endonuclease domain, which can be excluded via <i>MLH3</i> splice redirection to suppress expansion

2020-10-27

Abstract excerpt

Somatic expansion of the CAG repeat tract that causes Huntington’s disease (HD) is thought to contribute to the rate of disease pathogenesis. Therefore, factors influencing repeat expansion are potential therapeutic targets. Genes in the DNA mismatch repair pathway are critical drivers of somatic expansion in HD mouse models. Here, we have tested, using genetic and pharmacological approaches, the role of the endon...

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Identifiers and source

Literature Corpus work
e24e4dfb-ed48-5496-a8c7-668d90f38947
DOI
10.1101/2020.10.26.356238
Open publication

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Somatic CAG expansion in Huntington’s disease is dependent on the MLH3 endonuclease domain, which can be excluded via <i>MLH3</i> splice redirection to suppress expansionDOI 10.1101/2020.10.26.356238
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