Article

SARS-CoV2 infects pancreatic beta cells in vivo and induces cellular and subcellular disruptions that reflect beta cell dysfunction

2021-07-20

Abstract excerpt

<title>Abstract</title> <p>Increasing evidence of new-onset diabetes during the COVID19 pandemic indicates that the SARS-CoV2 virus may drive beta-cell dysfunction leading to diabetes, but it is unclear if it is a primary or secondary effect. Here, we present evidence of SARS-CoV-2 infection of pancreatic beta cells <italic>in vivo</italic> using a robust and reproducible non-human primates model of mild to moder...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 498f6e1b-9905-5794-89e5-bc4313223765
DOI: 10.21203/rs.3.rs-592374/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

SARS-CoV2 infects pancreatic beta cells in vivo and induces cellular and subcellular disruptions that reflect beta cell dysfunctionDOI 10.21203/rs.3.rs-592374/v1Read

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairmentSemantic proximity Read

Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cellsSemantic proximity Read

SARS-CoV-2 infection induces beta cell transdifferentiation.Semantic proximity Read

Limited extent and consequences of pancreatic SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagationSemantic proximity Read

Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD StudySemantic proximity Read

Glycolytic inhibitor 2-Deoxy-D-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virionsSemantic proximity Read

Glycolytic Inhibitor 2-Deoxy-D-Glucose Attenuates SARS-CoV-2 Multiplication in Host Cells and Weakens the Infective Potential of Progeny VirionsSemantic proximity Read

SARS-CoV-2 Infection Impacts Carbon Metabolism and Depends on Glutamine for Replication in Syrian Hamster AstrocytesSemantic proximity Read

PFKFB3 Depletion Activates β-Cell Replication by Cell Competitive Culling of Compromised β-Cells Under StressSemantic proximity Read

Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virionsSemantic proximity Read