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SARS-CoV-2 infection induces beta cell transdifferentiation.

Cell metabolism - 3 Aug 2021

Tang Xuming, Uhl Skyler, Zhang Tuo, Xue Dongxiang, Li Bo, Vandana J Jeya, Acklin Joshua A, Bonnycastle Lori L, Narisu Narisu, Erdos Michael R, Bram Yaron, Chandar Vasuretha, Chong Angie Chi Nok, Lacko Lauretta A, Min Zaw, Lim Jean K, Borczuk Alain C, Xiang Jenny, Naji Ali, Collins Francis S, Evans Todd, Liu Chengyang, tenOever Benjamin R, Schwartz Robert E, Chen Shuibing

Abstract excerpt

Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19. Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pancreatic islet cells were susceptible to SARS-CoV-2, eliciting a...

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Identifiers

PMID: 34081913
DOI: 10.1016/j.cmet.2021.05.015
PMCID: PMC8133495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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