Article

The membrane imposes a conformational directivity switch on receptor tyrosine kinase dimers

2026-05-26

Abstract excerpt

Structural fluctuations within a membrane protein propagate between domains, but the direction in which these fluctuations propagate has been inaccessible. Here we develop two causal inference frameworks, CASCADE and MERIT, that extract this direction from molecular dynamics trajectories. They reveal a quantity invisible to experiment: conformational directivity. In transmembrane (TM)–juxtamembrane (JM) dimers of...

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Literature Corpus work: 4979b3e1-025b-559e-ac6c-8db1c71fe677
DOI: 10.64898/2026.05.22.727318

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