Genetic profiling of patients with atopic dermatitis reveals immune and skin barrier variants associated with generalized eczema and optimal response to Dupilumab therapy.

doi:10.3389/fimmu.2026.1788831

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Article

Genetic profiling of patients with atopic dermatitis reveals immune and skin barrier variants associated with generalized eczema and optimal response to Dupilumab therapy.

Frontiers in immunology - 1 Jan 2026

Morelli Martina, Scaglione Giovanni Luca, Dattolo Anna, Galluzzo Marco, Scarponi Claudia, Moretta Gaia, Provini Alessia, Russo Filomena, Cocuroccia Barbara, Sordi Donatella, Talamonti Marina, Villella Valeria, Selvi Fabio Romano, Mercurio Laura, Paganini Claudia, Mortato Edoardo, Bianchi Luca, De Pità Ornella, Pallotta Sabatino, Scala Enrico, Albanesi Cristina, Madonna Stefania

Abstract excerpt

Background: Atopic dermatitis (AD) is a clinically heterogeneous immune-mediated skin disorder. The lack of reliable clinical stratification tools and predictive biomarkers for therapeutic response remains a critical unmet need to optimize treatment and advance precision dermatology. Objective: To investigate the association between genetic variants and AD phenotypes and response to Dupilumab as a potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42039188
DOI: 10.3389/fimmu.2026.1788831
PMCID: PMC13106602

Genes

FLG
KIF3A
RPTN
ADAM33
IL4R
IL5RA
IL6R
STAT6
TSLP

Provenance

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