Article

Functional Depth Biomarkers Distinguish Lung Squamous Cell Carcinoma from Lung Adenocarcinoma

2026-07-13

Abstract excerpt

<title>Abstract</title> <p>Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) exhibit fundamentally distinct pathway coordination architectures. We developed a framework integrating pathway activity inference from spatial transcriptomics data, spatial proximity based network construction, and functional depth analysis across 996 TCGA patients. Applying Fraiman-Muniz depth statistics, we generated...

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Literature Corpus work: 492357e0-136a-5693-8350-62c09ecfe0d6
DOI: 10.21203/rs.3.rs-9347794/v1

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