Article

Evaluating Sequence and Structural Similarity Metrics for Predicting Shared Paralog Functions

2024-10-13

Abstract excerpt

<h4>ABSTRACT</h4> Gene duplication is the primary source of new genes, resulting in most genes having identifiable paralogs. Over evolutionary time scales, paralog pairs may diverge in some respects but many retain the ability to perform the same functional role. Protein sequence identity is often used as a proxy for functional similarity and can predict shared functions between paralogs as revealed by synthetic...

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Literature Corpus work: 48e507b8-043f-5597-b542-e6bbd3dca8b8
DOI: 10.1101/2024.10.11.617835

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