Article

Leveraging protein language models and scoring function for Indel characterisation and transfer learning

2025-03-14

Abstract excerpt

1. Protein language models (PLMs) are increasingly used to assess the impact of genetic variation on proteins. By leveraging sequence information alone, PLMs achieve high performance and accuracy and can outperform traditional pathogenicity predictors specifically designed to identify harmful variants contributing to diseases. PLMs can perform zero-shot inference, making predictions without task-specific fine-tuni...

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Literature Corpus work: bbf74e34-d80a-5a47-b0e5-d2fbbf6622b3
DOI: 10.1101/2025.03.12.642715

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