Article

Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

2022-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Out of the several hundred copies of rRNA genes that are arranged in the nucleolar organizing regions (NOR) of the five human acrocentric chromosomes, ∼50% remain transcriptionally inactive. NOR-associated sequences and epigenetic modifications contribute to differential expression of rRNAs. However, the mechanism(s), controlling the dosage of active versus inactive rRNA genes in mammals is ye...

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Literature Corpus work: 48aa72f9-e3b9-52df-a28e-6563b011d997
DOI: 10.1101/2022.07.04.498693

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