Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions

Abstract excerpt

Despite decades of research into the molecular hallmarks of aging, geroscience lacks a unifying framework to guide the development of effective anti-aging interventions. Here, we integrate two leading evolutionary theories—the Disposable Soma Theory and Hyperfunction Theory—into a layered model of aging biology, the “Aging Onion”. In this framework, aging arises both from persistent activity of growth pathways and...

Topics

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• Caloric Restriction
• Dwarfism
• Growth Hormone
• Human Growth Hormone
• Insulin-Like Growth Factor I
• Longevity
• Models, Animal
• Yeasts

Identifiers and source

Literature Corpus work

4885a71b-eabf-5cff-bbc5-31e5b83363f4

DOI

10.32942/x25h23