Article
Evolutionary medicine: from dwarf model systems to healthy centenarians?
Science (New York, N.Y.) - 28 Feb 2003
Longo Valter D, Finch Caleb E
Abstract excerpt
Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span...
Topics
Join the communities discussing this publication.