Article

Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory Analysis

2025-09-02

Abstract excerpt

<h4>Background</h4> The continuous aging of the world’s population urges the improvement of early diagnosis of age-related diseases, such as Alzheimer’s disease (AD). Blood proteomes can detect systemic and organ-specific disease-related changes and are accessible by minimally invasive blood draws. <h4>Methods</h4> We explored the potential of proteomic and epigenetic aging clocks as complementary biomarkers to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4880b5df-8748-50c4-a27d-e8b27dbf8e61
DOI: 10.1101/2025.09.01.25334848

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory AnalysisDOI 10.1101/2025.09.01.25334848Read

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populationsSemantic proximity Read

A cerebrospinal fluid proteomic clock reveals opposing brain-aging programs and predicts neurological disease progressionSemantic proximity Read

Cellular Aging Signatures in the Plasma Proteome Record Human Health and DiseaseSemantic proximity Read

Comprehensive Comparison of Sixteen Markers of Biological Aging: Cross-Sectional and Longitudinal Results from the Berlin Aging Study II (BASE-II)Semantic proximity Read

Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank.Semantic proximity Read

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity Read

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity Read

Blood-Based Biomarkers in Alzheimer's Disease: Advancing Non-Invasive Diagnostics and PrognosticsSemantic proximity Read

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain healthSemantic proximity Read

Multiomics profiling of human plasma and CSF reveals ATN derived networks and highlights causal links in Alzheimer’s diseaseSemantic proximity Read

<i>APOE</i> genotype or presence of brain amyloid alters the plasma proteome in cognitively normal, elderly subjectsSemantic proximity Read

Genetic architecture of Alzheimer’s disease-related plasma biomarkersSemantic proximity Read