Article

Replication Capacity and Susceptibility of Nirmatrelvir-Resistant Mutants to Next-Generation Mpro Inhibitors in a SARS-CoV-2 Replicon System

2024-10-21

Abstract excerpt

<title>Abstract</title> <p>There is an ongoing need to expand the anti-SARS-CoV-2 armamentarium to include agents capable of suppressing replication of drug-resistant mutants emerging during monotherapy with approved direct-acting antivirals. Using a subgenomic SARS-CoV-2 replicon system, we studied the RNA replication capacity of nirmatrelvir (NTV)-resistant mutants and their susceptibility to next-generation Mp...

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Literature Corpus work: 486467dd-2c1a-54d1-92e9-5240f679b768
DOI: 10.21203/rs.3.rs-5286021/v1

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