Article

The evolution of the Human mitochondrial bc1 complex- adaptation for reduced rate of superoxide production?

2022-12-05

Abstract excerpt

The mitochondrial bc1 complex is a major source of mitochondrial superoxide. While bc1-generated superoxide plays a beneficial signaling role, excess production of superoxide lead to aging and degenerative diseases. The catalytic core of bc1 comprises three peptides -cytochrome b, Fe-S protein, and cytochrome c1. All three core peptides exhibit accelerated evolution in anthropoid primates. It has been suggested th...

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Literature Corpus work: 481ce6d6-ea1b-5ec2-ada6-9beb444cae67
DOI: 10.21203/rs.3.rs-2313577/v1

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