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Article

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.

Genes and immunity - 1 Apr 2008

Levinson R D, Du Z, Luo L, Monnet D, Tabary T, Brezin A P, Zhao L, Gjertson D W, Holland G N, Reed E F, Cohen J H M, Rajalingam R

Abstract excerpt

Birdshot chorioretinopathy (BCR), a chronic ocular inflammatory disease with characteristic choroidal lymphocytic infiltrates, has been strongly associated with human leukocyte antigen (HLA)-A29. Although HLA-A29 occurs frequently in all populations, BCR affects only a small percentage of HLA-A29-positive Caucasians, indicating additional susceptibility factors for BCR. Discovery of HLA class I-specific killer...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18340360
DOI: 10.1038/gene.2008.13

Genes

BCR
C2
KIR2DS2
KIR3DL1
KIR2DL1
KIR2DL2
KIR2DS1
KIR3DS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.PMID 18340360Read ↗

Killer immunoglobulin-like receptor genes in uveitis.Semantic proximity Read ↗

The Impact of HLA-A29 Homozygosity and of the Second HLA-A Allele on Susceptibility and Severity of Birdshot Chorioretinitis.Semantic proximity Read ↗

A study of KIR genes and HLA-C in Vogt-Koyanagi-Harada disease in Saudi Arabia.Semantic proximity Read ↗

ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers.Semantic proximity Read ↗

ERAP1, ERAP2, and two copies of HLA-Aw19 alleles increase the risk for Birdshot Chorioretinopathy in HLA-A29 carriersSemantic proximity Read ↗

Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.Semantic proximity Read ↗

Susceptibility to birdshot chorioretinopathy is restricted to the HLA-A29.2 subtype.Semantic proximity Read ↗

Single-cell profiling identifies a CD8<sup>bright</sup>CD244<sup>bright</sup>Natural Killer cell subset that reflects disease activity in HLA-A29-positive<i>birdshot chorioretinopathy</i>Semantic proximity Read ↗

HLA-A29 and Birdshot Uveitis: Further Down the Rabbit HoleSemantic proximity Read ↗

HLA-A29 and Birdshot ChorioretinopathySemantic proximity Read ↗

HLA-A alleles including HLA-A29 affect the composition of the gut microbiome: a potential clue to the pathogenesis of birdshot retinochoroidopathy.Semantic proximity Read ↗

Does the Interaction of KIR and HLA Affect the Development of Non-Infectious Uveitis?Semantic proximity Read ↗

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