Article

Free energy perturbation calculations of mutation effects on SARS-CoV-2 RBD::ACE2 binding affinity

2022-08-01

Abstract excerpt

The strength of binding between human angiotensin converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of viral spike protein plays a role in the transmissibility of the SARS-CoV-2 virus. In this study we focus on a subset of RBD mutations that have been frequently observed in infected individuals and probe binding affinity changes to ACE2 using surface plasmon resonance (SPR) measurements and free ene...

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Literature Corpus work: 47c3ab57-f601-59a4-a7c6-18fb7a906da1
DOI: 10.1101/2022.08.01.502301

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