Article

Myositis-specific autoantibodies recognizing Mi2 also target the autoimmune regulator (AIRE) protein at a shared PHD-zinc finger

2025-01-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> In dermatomyositis patients with anti-Mi2 autoantibodies, autoantibodies can enter muscle cells, leading to the aberrant expression of genes normally repressed by the Mi2/nucleosome remodeling and deacetylation (NuRD) complex. However, the mechanism by which autoantibodies interfere with Mi2/NuRD function remains unclear. This study aimed to identify additional autoantibodie...

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Literature Corpus work: 47bef06b-02c2-5c4e-844d-3d5ae8e8b54a
DOI: 10.1101/2025.01.15.633218

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