Article
Frequent genetic alterations in myositis autoantigen genes in cancer-associated dermatomyositis.
Annals of the rheumatic diseases - 1 Mar 2026
Moreno-Cárdenas Ana Belén, Ros Javier, Gil-Vila Albert, Datta Debayan, Fasani Roberta, Serna Garazi, Jimenez Jose, Trallero-Araguás Ernesto, Viaplana Cristina, Lostes Julia, Milisenda José César, Grau-Junyent Josep Maria, Lopez-Perez Raquel, Pinal-Fernández Iago, Nuciforo Paolo, Toledo Rodrigo A, Selva-O'Callaghan Albert
Abstract excerpt
OBJECTIVES: One-third of patients diagnosed with dermatomyositis harbour an occult cancer, a rare condition named cancer-associated dermatomyositis (CAD). Emerging evidence suggests that genetic alterations in autoantibody-related genes give rise to neoantigens and specific autoantibodies that initiate an autoimmune response characteristic of CAD. This study evaluated the prevalence of such genetic alterations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.